TRANSLATIONAL PHYSIOLOGY ATP/UTP activate cation-permeable channels with TRPC3/7 properties in rat cardiomyocytes
نویسندگان
چکیده
Julio Alvarez, Alain Coulombe, Olivier Cazorla, Mehmet Ugur, Jean-Michel Rauzier, Janos Magyar, Eve-Lyne Mathieu, Guylain Boulay, Rafael Souto, Patrice Bideaux, Guillermo Salazar, François Rassendren, Alain Lacampagne, Jérémy Fauconnier, and Guy Vassort Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 637, Université Montpellier 1, Unité de Formation et de Recherche de Médecine, Centre Hospitalier Universitaire (CHU) Arnaud de Villeneuve, Montpellier, France; Laboratorio de Electrofisiologı́a, Instituto de Cardiologı́a, Havana, Cuba; INSERM, Unité Mixte de Recherche (UMR) S621, Université Pierre et Marie Curie, CHU Pitié-Salpêtrière, Paris, France; Department of Physiology, University of Debrecen, Debrecen, Hungary; Pharmacology, Faculty of Medicine, University of Sherbrooke, Fleurimont, Quebec, Canada; and Department of Pharmacology, Institut de Génomique Fonctionnelle, Centre National de la Recherche Scientifique UMR 5203, INSERM Unité 661, Université Montpellier I and Université Montpellier II, Montpellier Cedex, France
منابع مشابه
ATP/UTP activate cation-permeable channels with TRPC3/7 properties in rat cardiomyocytes.
Extracellular purines and pyrimidines have major effects on cardiac rhythm and contraction. ATP/UTP are released during various physiopathological conditions, such as ischemia, and despite degradation by ectonucleotidases, their interstitial concentrations can markedly increase, a fact that is clearly associated with arrhythmia. In the present whole cell patch-clamp analysis on ventricular card...
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